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Roh's group found a lead compound ( 120 , Figure 24 ) with a thiazolidine-2,4-dione skeleton and its potential in the inhibition of IKK (IC 50 = 1500 nM), therefore, they tried to optimize this core via exploring the electron push-pull effect of the right moiety and analyze the SAR [194]

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MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome