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Furthermore, after 24, 48, 72, and 96 h after treatment DNA damage was observed in a dose- and time-dependent manner (Patlolla et al., 2009)

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If inadequate intrinsic factor is availableloss from aging or proton pump inhibitor useB12 deficiency symptoms such as macrocytic anemia, neurological disorders and psychiatric symptoms (memory loss, depression, confusion, paranoia) may occur

As with any therapy, long-term studies are still limited, so ongoing observation and clinical research will further define its safety profile

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Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia