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10.1053/gast.2002.34173 Gastroenterology

M.MengerK

Conclusions Our study provides a blueprint for systematic proactive experimental evaluation of missense variant effects on human enzymes using cell-based models, including experimental modeling of how the impact of variants depends on therapeutic context

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Most Studied Broccoli Glucosinolate Hydrolysis Compounds The hydrolysis of glucosinolates (GSLs) in broccoli primarily produces isothiocyanates (ITCs), which are more bioactive than their GSL precursors