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Karmee, S

As summarized in Table 1, macrophages, T lymphocytes, and vascular wall cells, through their distinct bidirectional immunometabolic regulatory networks, predominantly drive the formation of the inflammatory microenvironment, immune imbalance, and vascular remodeling, thereby promoting the diseases pathological progression

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However, increased urinary Cu excretion may not be seen in fulminant hepatic failure due to a concomitant hepatorenal syndrome with kidney failure and anuria