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However, due to the increased risk of adverse gastrointestinal (GI) and cardiovascular (CV) events, dosing in geriatric patients should be done with caution because of age-related decreases in renal function and concomitant disease and drug therapy

This dosage range derives from extrapolation of effective animal doses using standard interspecies scaling factors

Thiamin studies on volunteers have claimed an increase in mental acuity

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Yes, when performed by licensed professionals with sterile equipment, the risks are rare