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For adults under age 65, the easiest way to get B12 is to take at least one 2,000 mcg supplement each week or a daily dose of 50 mcg

This intrinsic vulnerability is compounded by a weak copper export system, characterized by low expression of ATP7A/B transporters, which facilitates toxic accumulation [100]

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GPX4 recruits the antioxidant glutathione to reduce reactive lipid peroxides into lipid alcohols, thus preventing spontaneous ferroptosis induction

However, the successful identification of the small intestine-specific NMN transporter Slc12a8 has partly answered this question [77]