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The depletion of thiol antioxidants in vivo triggers permanent genetic alterations that can predispose individuals to cancer or other genetic disorders

Thermal pretreatment promotes the protective effect of HSP70 against tendon adhesion in tendon healing by increasing HSP70 expression

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The TGF-1/NOX4/ROS pathway also appears to be linked with the mitochondrial metabolic pathways implicated in lung fibrogenesis

KEAP1 mutations, occurring in 1520% of NSCLC, disrupt the KEAP1-NRF2 pathway that normally regulates cellular responses to oxidative stress