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Yuan X-J, Wang J, Juhaszova M, Gaine SP, Rubin LJ

Glutathione is synthesized in a two-step process through the action of -glutamylcysteine synthetase (ECS or GSH1) and glutathione synthetase (GSH2) 42,43

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As a transcription factor that regulates the expression of antioxidant proteins, Nrf2 translocates from the cytoplasm to the nucleus under oxidative stress, where it binds to DNA promoters to initiate the transcription of antioxidant genes ( 3.3 Regulating cell death 3.3.1 Pyroptosis Pyroptosis is a form of programmed cell death that is intimately associated with neuroinflammation