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The significance of selenoproteins for human health revealed by inborn errors of metabolism

It binds to HGF with high affinity (Kd = 65 pM) and markedly augments the capacity of HGF to activate c-Met phosphorylation, even at subthreshold concentrations of the growth factor

Abstract Fragile X Syndrome (FXS) is the most frequent cause of inherited intellectual disabilities and autism spectrum disorders, characterized by cognitive deficits and autistic behaviors

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Through experiments in a PCOS mouse model and a KGN GC model, PLB significantly improved ovarian function, regulated hormone levels, enhanced antioxidant capacity, and promoted cell survival by inhibiting the ferroptosis pathway

Acting as a crucial sensor for assessing the nutritional status of eukaryotic cells, mTOR exhibits activation in response to a surplus of amino acid availability, thereby regulating an assortment of synthetic metabolic pathways essential for sustaining cellular growth [157]