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The relevance of an appropriate consumption of trace elements such as Se is due to its antioxidant and anti-inflammatory effect, since it has been reported that these patients have an increase in the physiological concentrations of reactive oxygen species (ROS) that can cause damage to cellular components, including proteins, lipids and DNA, that promote the destruction of cartilage and bone [11,12,13]

For instance, a CuO nanoplatform co-loaded with elesclomol potently induces copper-dependent cell death and enhances antitumor immunity

10.1016/S2214-109X(19)30045-2 201 RouzerC

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