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Indeed, several randomized controlled trials have just been completed or are poised to commence evaluating the effectiveness of novel drugs targeting both innate and adaptive immune pathways, including pro-inflammatory cytokines, the type I interferon system, B cell activation, B cell and T cell co-stimulation pathway, and ectopic germinal centre formation

(PubMed) Cheng TY, Barnett MJ, Kristal AR, et al

Nat Rev Cancer 18:767777 Li S, Liu S, Deng J, Akbay EA, Hai J, Ambrogio C, Zhang L, Zhou F, Jenkins RW, Adeegbe DO et al (2018b) Assessing therapeutic efficacy of MEK inhibition in a KRASG12C-driven mouse model of lung cancer

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