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There is no substantial evidence that HCG contributes to weight loss beyond the effects of calorie restriction

Once an appropriate serum sodium concentration is reached, subsequent therapy for chronic hyponatremia can include fluid restriction, the use of loop diuretics and oral urea (in patients with SIADH [syndrome of inappropriate antidiuretic hormone secretion)], oral salt tablets, or vasopressin receptor antagonists (319)

Clinical studies demonstrate that patients treated with tirzepatide achieve an average weight reduction exceeding 10 kilograms, substantially outperforming single-agonist therapies