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It can modulate sleep and wake functions

According to WHO guidelines, semen analysis should ideally be performed after 2-7 days of sexual abstinence, and at least two separate samples should be analysed to account for natural variation

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Correlations were assessed with Pearson or Spearman rho correlation tests using partial correlations to control for age, sex and TIV

De Simone R, Ajmone-Cat MA, Carnevale D, Minghetti L (2005) Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures