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Other reported NRF2 agonists with potential AD-modifying effects include flavonoids (eriodictyol), polyphenols (tannic acid), terpenoids (ginkgolide B), and lignans (forsythiaside A) (324327) ( Figure 7 )

188,445 Healthy cells primarily carry out OXPHOS in mitochondria to generate ATP

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the markers sphingosine-1-phosphate, sphingosine-2-phopshate kinase, sphingosine-1-phosphate receptor, adiponectin and the markers defined in Tables 1-8, as well as the techniques for determining the level of these markers, have also been defined in connection to the first method of the invention

Upon extracellular stimulation, multiple serine-threonine residues within the carboxy-terminal are sequentially phosphorylated leading to conformational changes allowing the SH3 and PX domains to interact with the proline-rich region of the p22 phox and PtdIns(3,4) P 2 , respectively (Ago et al., 1999