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1.10.2.2 Moderately severe poisoning Patients who have suffered a short-lived period of unconsciousness, convulsions, vomiting, and/or cyanosis (blood cyanide concentrations 2-3 mg/l) should be given * 100% oxygen, but for no longer than 12-24 h * 50 ml of 25% sodium thiosulfate solution (12.5 g) i.v

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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with pembrolizumab and platinum chemotherapy, are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

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Its prevalence peaks in the elderly population