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During a follow-up period of more than 20 years, the RCS models demonstrated significant nonlinear associations of both serum folate ( P high school degree), marital status (married, unmarried), family income to poverty ratio ( 5), smoking status (current smoker, ex-smoker, never smoker), physical activity (active, median, inactive), Healthy Eating Index, and self-reported general health (excellent, very good, good, fair, poor)

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While the number of subjects in this study for genomic analysis was small, the analysis of eight specimens per lung representing different degrees of emphysema from each individual allowed us to detect gene expression changes specifically associated with regional emphysema severity

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