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Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

A sore, swollen, or unusually pale tongue can also be a tell-tale sign

Methods: Micropatterned PHH islands, generated using soft lithography, were surrounded by 3T3-J2 fibroblasts (MPCC) +/- activated hepatic stellate cells (HSCs) to generate stellate cell-containing micropatterned tri-cultures (S-MPTCs)