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TFR2 was knocked down in MDA-MB-436 cells using siRNA and si-TFR2 1# was selected for further experiments, as it exhibited the highest knockdown efficiency (Fig

BPC 157 and Tissue Repair Research

British Journal of Pharmacology 153 :199-215

doi: 10.1016/j.cell.2015.07.046 8

After being phosphorylated, LAT binds to Grb2, Gads, PLC-1, and the guanine exchange factors, VAV and SOS, leading to the activation of PI3K and MAPK-dependent pathways and production of inflammatory cytokines (Fig