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Alalwan , Ziyad Al-Aly , Khurshid Alam , Fahmi Y

Single-cell RNA sequencing comparing healthy cartilage and osteoarthritic cartilage revealed a considerable increase in both inflammatory and fibrocartilage-like chondrocyte populations in OA tissues, with enrichment of genes involved in ferroptosis pathways (121), based on published transcriptomic analyses using standardized bioinformatics pipelines

It can directly enter the bloodstream via the lymphatic system, increasing absorption by 10-15 times

Future refined studies using key pathological centered around key pathological markers of cellular dysfunction will help uncover specific points of phenoconversion and phenotransition to identify the chronology of events leading to phenotypes associated with neurodegeneration

The criteria for exclusion were diabetes, malignancy, pregnancy, breastfeeding, and antibiotic use within 3 months prior to the study

Targeting SAMe-related pathways, including combination with anticancer drugs, could offer new therapeutic options