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Short-chain fatty acids, such as butyric acid, also indirectly promote the diversion of Tryptophan to indole metabolism in the microbiota by inhibiting IDO1 expression and STAT1 phosphorylation, further enhancing the AHR signaling pathway (Pant et al., 2023)

He X, Liu Y, Li K, Yang A, Wang R, Liu S

Schneider-Helmert D, Schoenenberger GA

Another highlight is the exploitation of various programmed cell death (PCD) mechanisms, including pyroptosis, ferroptosis, and cuproptosis, to amplify ICD and systemic antitumor immunity