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Consequently, mitophagy is primarily regulated indirectly in PDAC by targeting factors such as mitochondrial integrity, mitochondrial dynamics, autophagosome formation, and autolysosome formation [16] (Fig

This shift is further promotedespecially in visceral depotsby accumulation of CD8 + Tc1 and CD4 + Th1 cells (IFN-), by Th17 enrichment, and by a relative decline in regulatory T cells (Tregs) [944,945,946,947,948,949,950]