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Even though the role of polyP in the modulation of bone mineralization was suggested nearly 15 years ago (Leyhausen et al., 1998), only recently considerable advances were made in the study of polyP contribution to bone tissue development (Kawazoe et al., 2009

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(2022) 12:a040501

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Meanwhile, by eliminating MDSCs and promoting M1 macrophage polarization, ferroptosis inducers can effectively reverse cold tumors into hot tumors infiltrated by immune cells, fundamentally improving the microenvironment for immunotherapy (159)

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