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Komatsu M., Kimura T., Yazaki M., et al., Steatogenesis in AdultOnset Type II Citrullinemia Is Associated With DownRegulation of PPAR, Biochimica et Biophysica Acta, Molecular Basis of Disease 1852 (2015): 473481, 10.1016/J.BBADIS.2014.12.011

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In this context, ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation, plays a critical role in vascular injury and dysfunction ( Ferroptosis not only contributes to endothelial injury but also amplifies the inflammatory response in sepsis, creating a vicious cycle of vascular dysfunction and systemic inflammation ( In summary, ferroptosis plays a pivotal role in the pathophysiology of sepsis by contributing to endothelial injury, vascular dysfunction, and the amplification of systemic inflammation

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Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation