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These recurrent waves of increased concentrations of K + and astrocytic Ca 2+ cause cytotoxic edema (Hartings et al., 2017) and may potentially result in terminal depolarizations and falls in perfusion, causing secondary expansion of the infarct core at the expense of the penumbral region (Strong et al., 2007

And hypoxia could increase the expression of Zta, a protein that mediates the transition between latent and lytic EBV infection, which could in turn increase the amount of viral DNA replication in infected cells (102)

Biochem J, 2005

Teleost fish harbor their main hematopoietic niche in the kidney marrow (also called head kidney), which is regarded as homologous in structure and function to the mammalian bone marrow 28,29,30

The spectrin-actin network offers the mechanical pliability required for RBCs to distort while passing through slim blood vessels (6)

Moreover, gut microbial alterations, such as reduced Akkermansia muciniphila in severe periodontitis, can be restored via periodontal therapy or FMT, improving gut barrier function and ameliorating periodontal inflammation (Zhang et al., 2025)