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In this context, the use of natural compounds, such as dietary polyphenols could be of great aid to avoid the negative effects of normal therapies, acting as complementary therapies from the available armamentarium [584]

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In addition to these pivotal genes, more than 100 genes have been implicated in the pathogenesis of RA, including genes from the tumour necrosis factor and interleukin families, as well as the osteopontin family (Fig