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A high-fat meal induces low-grade endotoxemia: Evidence of a novel mechanism of postprandial inflammation

However, in the human body there are also present redox-active metals such as iron, which is the most abundant transition metal in healthy humans

The polar hydrophilic alkaloid trigonelline can be extracted from many plant species, including coffee beans and fenugreek seeds, and has been shown to significantly sensitize cancer cells to ferroptosis inducers by inhibiting NRF2

[DOI] [PubMed] [Google Scholar] Radonji NV, Kneevi ID, Vilimanovich U, Kravi-Stevovi T, Marina LV, Nikoli T, Todorovi V, Bumbairevi V, Petronijevi ND

Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)

The possibility of overlapping other autoimmune diseases (e.g., thyroid damage, Addisons disease, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel diseases, autoimmune hepatitis, vitiligo) should be known in the case of children with type I diabetes ( Baig S