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Consequently, UPR is activated to resolve this protein-folding defect and thus to restore ER homeostasis

Impaired insulin secretion after tolbutamide and glucagon stimulation tests: evidence of insulin deficiency

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10.1186/s40360-022-00622-1 241 YangR.ChangQ.MengX.GaoN.WangW

A number of plausible anti-cancer mechanisms have been proposed, such as indirect generation of hydrogen peroxide, enzyme cofactor activities (e.g., collagen synthesis, HIF hypoxic response regulation, TET and JHDM epigenetic regulation), as well as antioxidant and anti-inflammatory functions