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Reactive O2 species molecules include peroxide (H2O2) and superoxide anions (O2 with an unpaired electron)

Over time, or through acute injury, they break down

Numerous studies demonstrate that the GM contributes to bone homeostasis by modulating the release of numerous hormones linked to bone metabolism, such as estrogen (242), IGF-1, 5-HT, PTH, glucagon-like peptide-1 (GLP-1), and leptin (243)

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The Glucagon-Like Peptide-1 Receptor Agonist Liraglutide Improves Hypoxia-Induced Pulmonary Hypertension in Mice Partly via Normalization of Reduced ET B Receptor Expression