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Individuals who have difficulty absorbing nutrients or who follow strict plant-based diets may have a higher risk of developing the deficiency

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Common (Usually Transient) Side Effects Water retention or puffiness Carpal tunnel-like symptoms Joint stiffness (often temporary) Mild insulin resistance if overdosed How We Monitor Baseline and follow-up IGF-1 levels Body composition changes Symptom tracking and dose titration Our goal is to maintain IGF-1 in the high-normal physiologic range , not to create supraphysiologic levels

Side effects are generally minimal, but some individuals may experience gastrointestinal discomfort

Lowering the risk of autism spectrum disorder with folic acid: can there be too much of a good thing?. The American Journal of Clinical Nutrition 115.5 (2022): 1268-1269