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In summary, the localized expression of MMPs in tissues, their dynamic changes in bodily fluids and their value as predictors of treatment response provide crucial molecular basis for assessing GBM invasiveness, predicting patient prognosis, real-time monitoring of disease status and guiding individualized treatment strategies

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Some sensitive patients may benefit from microdosing (below 0.25 mg) or customized compounded formulations to improve tolerance

However, they all differed in the methodology and criteria used to identify vitamin B 12 deficiency as well as in the definition used