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Expression and polarized localization of the hemochromatosis gene product hfe in retinal pigment epithelium

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Compared with NRAS activating mutations at positions 12 and 13, NRAS Q61 mutations exert a stronger activating effect on the MAPK pathway since codon 61 is the catalytic residue for GTP hydrolysis and Q61 mutation impedes the return of RAS to an inactive GDP-bound state (92)

In addition, Met can provide the carbon skeleton for polyamine synthesis (Figure 1)

Wang L, Wang N, Zhang W et al (2022) Therapeutic peptides: current applications and future directions