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Acknowledgements This work was supported by the National Natural Science Foundation of China (82273092) to LFF and Natural Science Foundation in Zhejiang province (LD22H160003) to XW

G6PD is the major source of the cytosolic NADPH pool (see the Metabolic Sources and Cellular Distribution of the NAD(H) and NADP(H) Couples section)

Distribution studies showed that in rabbits, following inhalation or injection, the highest concentrations of morpholine were found in the kidney, whereas, in rats, high concentrations were found in muscle

Cells were grown to 7080% confluence in 100-mm dishes and then treated with 100 M Acivicin for 24 h

Zarrouk A, Vejux A, Mackrill J, OCallaghan Y, Hammami M, OBrien N, et al

In hospital settings, it is also used as an antidote for paracetamol overdose (IV formulation at doses of up to 150mg/kg) and in nebulized format in patients with acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis)