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Additional refinements to its structure to limit both phase 1 and phase 2 hepatic metabolism and first pass clearance, to reduce metabolism by gastric enzymes and enhance oral bioavailability, and to diminish polar surface area and overall size to facilitate BBB penetrability are currently in progress

Selenium supports antioxidant defense

But thymic research kind of fell out of favor the last few decades

As for in vivo validation, with/without DEHP-treated BRCA cell lines could be implanted into mice to assess their tumorigenicity