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Although we were successful in ectopically expressing CDO in our cell culture system, the absolute level of maximal expression for either of the CDO constructs was far less than what is normally found in vivo

Miller (2012)

N Engl J Med 2011, 365 (17):1576-1585

Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand

Accelerated organ aging confers 2050% higher mortality risk, and organ-specific diseases relate to faster aging of those organs

Vigilant monitoring and management of these side effects are critical for therapy safety and continuity