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In particular, it was experimentally shown that activity of complex I of the respiratory chain can modulate lifespan (Ripa et al., 2017) and cardiac health (Heid et al., 2017) during aging and that decay of proteasome activity is an early event during aging causing loss of stoichiometry in protein complexes (Kelmer Sacramento et al., 2020)

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Its synthesis is highly dependent on mitochondrial integrity and the supply of ATP

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