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If you plan to resume, restart at the full dose rather than titrating back up, since the break period allows receptor resensitization

Research suggests that it works by stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (fat accumulation), particularly in stubborn fat deposits such as the abdomen and thighs

Research Compound

The SURMOUNT-3 trial showed that combining tirzepatide with intensive lifestyle intervention produced 26.6% weight loss versus approximately 21% with medication alone over similar timeframes

Sampson CM, Dimet AL, Neelakantan H, et al

The difference between those who do and those who don't almost always comes down to one variable: whether they're injecting fasted and maintaining a caloric deficit