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Therefore, to explore whether there is an association between neutrophils and ferroptosis, another study explored the role of GPX4 in neutrophil ferroptosis and identified two key factors, namely serum autoantibodies and IFN- (170), both of which induce iron apoptosis in neutrophils by activating the CaMKIV/CREM axis, leading to SLE neutropenia

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This dual approach allows for the evaluation of compound warhead activity while assessing the in vivo clearance ability, facilitating the screening of compounds with appropriate reactivity, selectivity, and safety