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For example, p300/CBP promotes high mobility group box 1 lactylation while simultaneously inhibiting SIRT1 deacetylase activity via the Hippo/YAP pathway, thereby activating acetylation and ultimately exacerbating sepsis progression (75)

Annu Rev Genet 47: 121137

Propionate mitochondrial toxicity in liver and skeletal muscle: Acyl CoA levels

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Moreover, AuNPs-d-PLL-PEG, at both 25 and 50 nM siRNA, showed no significant difference in fluorescence compared to control samples