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Inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and leaky gut syndrome are some of the intestinal pathologies that can be caused by endotoxin exposure

Although most NSAID-driven studies remain at preclinical stages, they suggest that COX-2 inhibition alone or in combination with chemotherapy or immunotherapy can reverse aspects of the inflamed, immunosuppressive microenvironment

It also has antioxidant activity besides its antidepressant effect (Altuner et al

doi: 10.1097/XEB.0000000000000277 26 HigginsJPTThomasJChandlerJCumpstonMLiTPageMJet al

Similarly, Doll and colleagues showed that the rapid MOR dephosphorylation at S375 involves the protein phosphatase 1 which increases the recycling of receptors contained in endosomes to cell surface (Doll et al., As indicated above, DOR was initially described as a receptor sorted to lysosomal degradation (Tsao and Von Zastrow, 2000)

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