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Currently undergoing late-stage clinical trials for the treatment of obesity and type 2 diabetes, CagriSema combines semaglutide with a dual amylin and calcitonin receptor agonist called cagrilintide

Its remarkable structure enables it to neutralise free radicals from both hydrophilic and hydrophobic boundaries (watery and fatty) of cell membranes, making it a more powerful antioxidant than others

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It should be recurrently situated at the beginning of the first -helix of the thioredoxin fold, which does not mean that extra -helices cannot be found before

The later this happens in the design process, the fewer options are available to reduce costs and to affect change

& Deshaies, R.J