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The FDAs decision was supported by the Phase III SUNLIGHT trial, where the LonsurfAvastin combination led to a median overall survival of 10.8 months versus 7.5 months on Lonsurf monotherapy, for a 39% reduction in risk of death

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Moreover, interspecies differences in ovarian tissue architecture, mitochondrial density, and endogenous antioxidant capacity can lead to variable outcomes, with certain antioxidants demonstrating stronger protective effects in rodent models compared to human or ruminant tissues (93)