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Each component has attracted attention in experimental models related to cellular signaling, tissue remodeling, and regenerative biology

Through integrating findings from recent studies, this work aims to shed light on the potential of microbiota-targeted therapies in managing diseases that involve the gut, liver, and kidneys (Guo et al., 2 Composition and function of gut microbiota The gut microbiota, a diverse community of microorganisms living in the gastrointestinal tract, is vital for human health

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Bruscia EM, et al

doi: 10.1016/j.chemosphere.2012.10.066 28 GuptaD

Upon ligand binding, TR II phosphorylates and activates TR I, forming a heteromeric receptor complex that initiates downstream signaling through both SMAD-dependent and SMAD-independent pathways, such as ERK, p38, JNK, and PI3K-Akt cascades [33, 36, 39]