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The 500 mcg per-capsule dose mirrors the per-day intake used in the bulk of rodent oral studies, and the gastric origin of the parent molecule provides a biological rationale for stability through the GI tract a feature documented across multiple oral-administration preclinical models

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Thrombin when activated through the tissue factor-mediated extrinsic pathway and subsequent prothrombinase activity 50 , amplifies local coagulation through positive feedback in the coagulation cascade 51

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