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The ferrous heme iron (Fe 2+ ) of the prosthetic group is spontaneously transformed into an oxidized ferric (Fe 3+ ) form, but under oxidative stress conditions a higher oxidation ferryl heme (Fe 4+ ) is also formed

This inflammation can also occur in the central nervous system [58]

CIMG_06944 has a predicted signal sequence suggesting that it is a secreted protein too

[DOI] [PubMed] [Google Scholar] 18.Waugh D.S

Higher Glutamate levels in microglial culture supernatant contribute towards N2a cell death by competitively inhibiting xCT present on immature neurons in the developing brain, which is low in basal cellular GSH level 19

(PubMed) Goodwin JS, Goodwin JM, Garry PJ