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OS occurs even within the sperm: while, in fact, spermatozoa have inherent scavenging capabilities, they are impaired in cases of teratozoospermia [210,211,212]

Briefly, mice were subjected to mid-ventral laparotomy, and resection of right medial, left medial and left lateral lobes were performed after separate ligation

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This dual approach allows for the evaluation of compound warhead activity while assessing the in vivo clearance ability, facilitating the screening of compounds with appropriate reactivity, selectivity, and safety