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Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress

10.1126/scisignal.aax6660 73 GutscherM.PauleauA.-L.MartyL.BrachT.WabnitzG

Thus, more than genes of major effect, evidence suggest that there are multiple susceptibility loci, each one with small effect

Aspartame did not induce chromosomal aberrations in the bone marrow cells of C57BL/6 mice exposed at a dose of 40 or 400 mg/kg bw per day by oral gavage for 5 days (Durnev et al., 1995)

Muscle mass decreases by about 3% to 8% per decade after age 30, and this loss accelerates after 50

Adrenal overactivation in response to chronic gut inflammation produces a flattened diurnal cortisol curve with characteristic early afternoon collapse