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For instance, old mice were about 6.5-fold and fourfold more sensitive to the lethal toxicity of lipopolysaccharide and exogenous TNF than young controls, respectively

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464 Despite efficacy in inhibiting ferroptosis, non-RTA ferroptosis inhibitors are often perceived as more druggable due to their specific protein targets

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1 Introduction Cardiovascular diseases (CVDs), encompassing ischemic heart disease, atherosclerosis, heart failure (HF), and coronary artery disease, constitute the predominant cause of global mortality and disability ( Substantial knowledge gaps persist in understanding the molecular mechanisms underlying cardiomyocyte mitochondrial dysfunction and the spatiotemporally regulated metabolic networks

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