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Lancet 2, 11701172.10.1016/S0140-6736(88)90236-X 58 LaronZ.PertzelanA.MannheimerS

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Generally, chronic treatment with SOD or SOD mimetics have evidently shown neuroprotective effects in ageing mice such as reduction in lipid peroxidation, nucleic oxidation and ROS concentrations, and improve age related-cognitive decline, mainly by neutralizing the age-dependent OS increase in hippocampus and amygdala (Clausen et al., 2010)