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Microbiology (2021)

87 The lack of robust human data is the elephant in the room: we simply dont have the clinical trials to know if the amazing results in rats will translate to people, or if long-term use might introduce serious side effects

This historical context has perpetuated a bias favoring fair skin, leading to widespread use of skin-lightening products

provided evidence that the interplay between the signals of mechanistic target of rapamycin kinase (mTOR) and GPX4 modulates autophagydependent ferroptosis in human pancreatic cancer cells, and the downregulated expression of GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy [38]

3 Intestinal permeability Semi-permeability or selective permeability is a crucial feature of the intestinal wall

Studies show a generally favorable short-term safety profile, with most side effects being mild, such as fever, headache, nausea, or fatigue