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Parsons RB, Smith SW, Waring RH, Williams AC, Ramsden DB (2003) High expression of nicotinamide N -methyltransferase in patients with idiopathic Parkinsons disease

The passage of the polypeptide into the endoplasmic reticulum (ER) removes the signal peptide, while the nascent IGF-1 prohormone (proIGF-1) is emerging, retaining the E-domain

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JAMA, 327 (2), 138150

They may also support nerve health, improve mood in cases of depression, and enhance cognitive function